Prof. dr hab. Jolanta Jura (nee Kwiatkowska) Prof. dr hab. Jolanta Jura (nee Kwiatkowska)

Address:

 

Department of General Biochemistry

Faculty of Biochemistry, Biophysics and Biotechnology

Jagiellonian University

ul. Gronostajowa 7

30-387 Kraków

 

Room: B125

Phone: 12 664 63 59

E–mail: jolanta.jura@uj.edu.pl

 

Education and Titles:

 

2014 – Professor, (molecular biology), Jagiellonian University, Krakow

2000 – DSc in Biology (habilitation; human genetics), A. Mickiewicz University, Poznan

1994 - Ph.D. in Biology (human genetics), Marcinkowski Medical Academy, Poznan

1990 - MSc in Biology (human genetics), M. Copernicus University, Torun

 

Positions:

 

since 2000 – Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland

1990-2000 - Polish Academy of Sciences, Institute of Human Genetics, Poznan

 

Honors and awards:

 

2010 – First Award of the Rector of Jagiellonian University  for scientific achievements (team award)

2009 - Servier Award and Polish Society of Diabetology -  "Hope giving discoveries"  for the best project

2000 - J. Sniadecki's Award for scientific achievements: "Characteristic and  identification of mutations in human genes: TSC1, XPMC2, RalGDS, DMD, RYR1 and APC" (team award).

1999 – Scientific Committee City of Poznan award  for scientific achievements: „Molecular background of human and animal genetic diseases" (team award).

1996 – Fellowship of Fundation for Polish Science – one year fellowship at Brigham and Women's Hospital, Harvard Medical School, in Boston

 

Internships and work abroad:

 

2010 - Marie Curie Host Fellowships for the Transfer of Knowledge, FP6 project; Laboratory of Oncology, G. Gaslini Institute, Genova, Italy; 2 months

2007 - Marie Curie Host Fellowships for the Transfer of Knowledge, FP6 project, Institute of Biomedical and Biological Sciences, Glasgow University; 2 months.

1996 – 1998 - Brigham and Women's Hospital, Harvard Medical School, Boston, USA – 2 years

1995 - Human Genetic Institute, Bonn, Germany; 2 weeks

1991 - Human Genetic Institute, Getingen, Germany; 3 months

 
Professional Societies:
 

Polish Society for Biochemistry, member and head of Krakow Branch

European Society for Dermatological Research

Polish Society of Human Genetics

 

Subject of interest:

  • regulation of inflammatory processes

  • signals regulating NFkappaB activity

  • MCPIP1 – Rnase regulating mRNA stability - its role in diseases with inflammatory background

  • inflammatory processes and adipogenesis and carcinogenesis

  • nanoparticles and their effects on cell biology

 

Most significant publications:

 

1. Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. Genomics. 1997 Sep 15;44(3):350-4. PubMed PMID: 9325058.

 

2. van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP,  Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science. 1997 Aug 8;277(5327):805-8. PubMed PMID: 9242607

 

3. Humphrey D, Kwiatkowska J, Henske EP, Haines JL, Halley D, van Slegtenhorst M, Kwiatkowski DJ. Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1. Ann Hum Genet. 1997 Jul;61(Pt 4):299-305. PubMed PMID: 9365783

 

4. Kwiatkowska J, Jozwiak S, Hall F, Henske EP, Haines JL, McNamara P, Braiser J,Wigowska-Sowinska J, Kasprzyk-Obara J, Short MP, Kwiatkowski DJ. Comprehensivemutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance. Ann Hum Genet. 1998 Jul;62(Pt 4):277-85. PubMed PMID: 9924605

 

5. Kwiatkowska J, Wigowska-Sowinska J, Napierala D, Slomski R, Kwiatkowski DJ. Mosaicism in tuberous sclerosis as a potential cause of the failure of molecular diagnosis. N Engl J Med. 1999 Mar 4;340(9):703-7. PubMed PMID: 10053179

 

6. Mizgalska D, Wegrzyn P, Murzyn K, Kasza A, Koj A, Jura J, Jarzab B, Jura J. Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA. FEBS J. 2009 Dec;276(24):7386-99. doi: 10.1111/j.1742-4658.2009.07452.x. Epub . PubMed PMID: 19909337

 

7. Skalniak L, Mizgalska D, Zarebski A, Wyrzykowska P, Koj A, Jura J. Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase. FEBS J. 2009 Oct;276(20):5892-905. doi: 10.1111/j.1742-4658.2009.07273.x. Epub 2009 Sep 11. PubMed PMID: 19747262

 

Publications from last 4 years:

1. Kotlinowski J, Bukowska-Strakova K, Koppolu A, Kosińska J, Pydyn N, Stawinski P, Wilamowski M, Nowak W, Józkowicz A, Baran J, Płoski R, Jura J. A Novel Monoallelic Nonsense Mutation in the NFKB2 Gene Does Not Cause a Clinical Manifestation. Front. Genet. 2019; 10, 140. PubMed PMID: 30863427

 

2. Marona P, Górka J, Kotlinowski J, Majka M, Jura J, Miekus K. C-Met as a Key Factor Responsible for Sustaining Undifferentiated Phenotype and Therapy Resistance in Renal Carcinomas. Cells 2019; 8, 272. PubMed PMID: 30909397

 

3. Wilamowski M, Gorecki A, Dziedzicka-Wasylewska M, Jura J. Substrate specificity of human MCPIP1 endoribonuclease. Sci. Rep. 2018; 8. PubMed PMID: 29743536

 

4. Lichawska-Cieslar A, Pietrzycka R, Ligeza J, Kulecka, M, Paziewska A, Kalita A, Dolicka D, Wilamowski M, Miekus K, Ostrowski J, Mikula M, Jura J. RNA sequencing reveals widespread transcriptome changes in a renal carcinoma cell line. Oncotarget 2018; 9, 8597–8613. PubMed PMID: 29492220

 

5. Losko M, Lichawska-Cieslar A, Kulecka M, Paziewska A, Rumienczyk I, Mikula M, Jura, J. Ectopic overexpression of MCPIP1 impairs adipogenesis by modulating microRNAs. Biochim. Biophys. Acta - Mol. Cell Res. 2018; 1865, 186–195. PubMed PMID: 28939056

 

6. Marona P, Górka J, Mazurek Z, Wilk W, Rys J, Majka M, Jura J, Miekus K. MCPIP1 Downregulation in Clear Cell Renal Cell Carcinoma Promotes Vascularization and Metastatic Progression. Cancer Res. 2017; doi:10.1158/0008-5472.CAN-16-3190 PubMed PMID: 29743536

 

7. Bugara B, Konieczny P, Wolnicka-Glubisz A, Eckhart L, Fischer H, Skalniak L, Borowczyk-Michalowska J, Drukala J, Jura J. MCPIP1 contributes to the inflammatory response of UVB-treated keratinocytes. J Dermatol Sci. 2017 Mar 25. pii: S0923-1811(17)30492-9. doi: 10.1016/j.jdermsci.2017.03.013. [Epub ahead of print] PubMed PMID: 28377026

 

8. Lipert B, Wilamowski M, Gorecki A, Jura J. MCPIP1, alias Regnase-1 binds and cleaves mRNA of C/EBPβ. PLoS One. 2017 Mar 22;12(3):e0174381. doi: 10.1371/journal.pone.0174381. eCollection 2017. PubMed PMID: 28328949

 

9. Ligeza J, Marona P, Gach N, Lipert B, Miekus K, Wilk W, Jaszczynski J, Stelmach A, Loboda A, Dulak J, Branicki W, Rys J, Jura J. MCPIP1 contributes to clear cell renal cell carcinomas development. Angiogenesis. 2017 Feb 14. doi: 10.1007/s10456-017-9540-2. [Epub ahead of print] PubMed PMID: 28197812

 

10. Losko M, Kotlinowski J, Jura J. Long Noncoding RNAs in Metabolic Syndrome Related Disorders. Mediators Inflamm. 2016;2016:5365209. Epub 2016 Nov 2. Review. PubMed PMID: 27881904

 

11. Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, Koziel J. MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production. J Innate Immun. 2016;8(6):564-578. Epub 2016 Aug 12. PubMed PMID: 27513529

 

12. Wawro M, Kochan J, Krzanik S, Jura J, Kasza A. Intact NYN/PIN-Like Domain is Crucial for the Degradation of Inflammation-Related Transcripts by ZC3H12D. J Cell Biochem. 2017 Mar;118(3):487-498. doi: 10.1002/jcb.25665. Epub 2016 Nov 10. PubMed PMID: 27472830

 

13. Ruiz-Romeu E, Ferran M, Giménez-Arnau A, Bugara B, Lipert B, Jura J, Florencia EF, Prens EP, Celada A, Pujol RM, Santamaria-Babí LF. MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A. J Invest Dermatol. 2016 Aug;136(8):1599-607. doi: 10.1016/j.jid.2016.04.030. Epub 2016 May

PubMed PMID: 27180111

 

14. Boratyn E, Nowak I, Horwacik I, Durbas M, Mistarz A, Kukla M, Kaczówka P, Łastowska M, Jura J, Rokita H. Monocyte Chemoattractant Protein-Induced Protein 1 Overexpression Modulates Transcriptome, Including MicroRNA, in Human Neuroblastoma Cells. J Cell Biochem. 2016 Mar;117(3):694-707.. doi: 10.1002/jcb.25354. Epub 2015 Sep 8. PubMed PMID: 26308737

 

15. Labedz-Maslowska A, Lipert B, Berdecka D, Kedracka-Krok S, Jankowska U, Kamycka E, Sekula M, Madeja Z, Dawn B, Jura J, Zuba-Surma EK. Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells. PLoS One. 2015 Jul 27;10(7):e0133746. doi: 10.1371/journal.pone.0133746. eCollection 2015. PubMed PMID: 26214508

16. Pośpiech E, Ligęza J, Wilk W, Gołas A, Jaszczyński J, Stelmach A, Ryś J, Blecharczyk A, Wojas-Pelc A, Jura J, Branicki W. Variants of SCARB1 and VDR Involved in Complex Genetic Interactions May Be Implicated in the Genetic Susceptibility to Clear Cell Renal Cell Carcinoma. Biomed Res Int. 2015;2015:860405. doi: 10.1155/2015/860405. Epub 2015 Apr 6. PubMed PMID: 25945350