Address:

• Department of General Biochemistry
• Faculty of Biochemistry, Biophysics and Biotechnology
• Jagiellonian University
• ul. Gronostajowa 7
• 30-387 Kraków
• Room: B125
• Phone: 12 664 63 59
• E–mail: jolanta.jura@uj.edu.pl

Education and Titles:

2014 – Professor, (molecular biology), Jagiellonian University, Krakow

2000 – DSc in Biology (habilitation; human genetics), A. Mickiewicz University, Poznan

1994 - Ph.D. in Biology (human genetics), Marcinkowski Medical Academy, Poznan

1990 - MSc in Biology (human genetics), M. Copernicus University, Torun

Positions:

1990 - 2000 - Institute of Human Genetics, Polish Academy of Sciences, Poznan; position: assistant, senior assistant

2000 - 2010 -  Department of Cellular Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: adjunct

2010 - 2014 - Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: associate professor

since 2014 - Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: professor

2014 - 2020 - Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: Vice-dean for Research and Intenational Relations of the BBB Faculty

since 2020 - Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow; position: Dean of the BBB Faculty

Honors and awards:

2023 - Member of the AcademiaNet nominated by the Foundation for Polish Science

2022 and 2023 - PhD student awarded during FEBS Congress for the best poster presentation

2022 - First Award of the Rector of Jagiellonian University for scientific achievements (team award)

2010 - First Award of the Rector of Jagiellonian University for scientific achievements (team award)

2009 - Servier Award and Polish Society of Diabetology - "Hope giving discoveries"  for the best project

2000 - J. Sniadecki's Award for scientific achievements: "Characteristic and  identification of mutations in human genes: TSC1, XPMC2, RalGDS, DMD, RYR1 and APC" (team award).

1999 – Scientific Committee City of Poznan award  for scientific achievements: „Molecular background of human and animal genetic diseases" (team award).

1996 – Fellowship of Fundation for Polish Science – one year fellowship at Brigham and Women's Hospital, Harvard Medical School, in Boston

Internships and work abroad:

2010 - Marie Curie Host Fellowships for the Transfer of Knowledge, FP6 project; Laboratory of Oncology, G. Gaslini Institute, Genova, Italy; 2 months

2007 - Marie Curie Host Fellowships for the Transfer of Knowledge, FP6 project, Institute of Biomedical and Biological Sciences, Glasgow University; 2 months.

1996 – 1998 - Brigham and Women's Hospital, Harvard Medical School, Boston, USA – 2 years

1995 - Human Genetic Institute, Bonn, Germany; 2 weeks

1991 - Human Genetic Institute, Getingen, Germany; 3 months

Professional Societies:

Polish Society for Biochemistry, member of the Presidium of the Management Board

European Society for Dermatological Research, member

Polish Society of Human Genetics, member

Federation of European Biochemical Societies, member of the international committee for the evaluation of scholarship applications

Subject of interest:

·         regulation of inflammatory processes

·         signals regulating NFkappaB activity

·         MCPIP1 – Rnase regulating mRNA stability - its role in diseases with inflammatory background

·         inflammatory processes and carcinogenesis

·         skin homeostasis and pathological processes of this organ

Most significant publications:

1. Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. Genomics. 1997 Sep 15;44(3):350-4. PubMed PMID: 9325058.

2. van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP,  Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science. 1997 Aug 8;277(5327):805-8. PubMed PMID: 9242607

3. Humphrey D, Kwiatkowska J, Henske EP, Haines JL, Halley D, van Slegtenhorst M, Kwiatkowski DJ. Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1. Ann Hum Genet. 1997 Jul;61(Pt 4):299-305. PubMed PMID: 9365783

4. Kwiatkowska J, Jozwiak S, Hall F, Henske EP, Haines JL, McNamara P, Braiser J,Wigowska-Sowinska J, Kasprzyk-Obara J, Short MP, Kwiatkowski DJ. Comprehensivemutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance. Ann Hum Genet. 1998 Jul;62(Pt 4):277-85. PubMed PMID: 9924605

5. Kwiatkowska J, Wigowska-Sowinska J, Napierala D, Slomski R, Kwiatkowski DJ. Mosaicism in tuberous sclerosis as a potential cause of the failure of molecular diagnosis. N Engl J Med. 1999 Mar 4;340(9):703-7. PubMed PMID: 10053179

6. Mizgalska D, Wegrzyn P, Murzyn K, Kasza A, Koj A, Jura J, Jarzab B, Jura J. Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA. FEBS J. 2009 Dec;276(24):7386-99. PubMed PMID: 19909337

7. Skalniak L, Mizgalska D, Zarebski A, Wyrzykowska P, Koj A, Jura J. Regulatory feedback loop between NF-kappaB and MCP-1-induced protein 1 RNase. FEBS J. 2009 Oct;276(20):5892-905. PubMed PMID: 19747262

Publications from last 5 years:

1. Lichawska-Cieslar A, Szukala W, Eckhart L, Jura J. MCPIP3/Regnase-3 binds 14-3-3 proteins and contributes to the regulation of the cell cycle in human immortalized keratinocytes. Sci Rep. 2025;15(1):33222. PubMed PMID: 41006702

2. Galka-Marciniak P, Urbanek-Trzeciak MO, Kuznicki D, Szostak N, Tire A, Nawrocka-Muszynska PM, Chojnacka K, Suszynska M, Klonowska K, Czubak K, Machowska M, Philips A, Maksin K, Susok L, Sand M, Rys J, Jura J, Ratajska M, Dams-Kozlowska H, Kowalewski J, Lewandowska MA, Kozlowski P. Whole-miRNome sequencing: a panel for the targeted sequencing of all human miRNA genes. Nucleic Acids Res. 2025;53(16):gkaf812. PubMed PMID: 40867048

3. Łabędź-Masłowska A, Wieczorek J, Mierzwiński M, Sekuła-Stryjewska M, Noga S, Rajca J, Duda P, Milian-Ciesielska K, Karnas E, Kmiotek-Caller K, Szkaradek A, Madeja Z, Ficek K, Jura J, Zuba-Surma E. Evaluation of the Safety and Regenerative Potential of Human Mesenchymal Stem Cells and Their Extracellular Vesicles in a Transgenic Pig Model of Cartilage-Bone Injury In Vivo - Preclinical Study. Stem Cell Rev Rep. 2025;21(4):1075-1095. PubMed PMID: 40380984

4. Lichawska-Cieslar A, Szukala W, Pilat P, Eckhart L, Szepietowski JC, Jura J. Cell Commun Signal. MCPIP3 orchestrates the balance of epidermal proliferation and differentiation. 2025;23(1):175. PubMed PMID: 40200325

5. Marona P, Myrczek R, Piasecka I, Gorka J, Kwapisz O, Pospiech E, Rys J, Jura J, Miekus K. The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis. Cell Commun Signal. 2025;23(1):28. PubMed PMID: 39815326

6. Żurawek D, Pydyn N, Major P, Szade K, Trzos K, Kuś E, Pośpiech E, Małczak P, Radkowiak D, Budzyński A, Chłopicki S, Jura J, Kotlinowski J. Diosmetin alleviates TNFα-induced liver inflammation by improving liver sinusoidal endothelial cell dysfunction. Biomed Pharmacother. 2025;183:117843. PubMed PMID: 39813788

7. Berniak K, Moradi A, Lichawska-Cieslar A, Szukala W, Jura J, Stachewicz U. Controlled therapeutic cholesterol delivery to cells for the proliferation and differentiation of keratinocytes. J Mater Chem B. 2024;12(43):11110-11122. PubMed PMID: 39466636

8. Lichawska-Cieslar A, Szukala W, Ylla G, Machaj G, Ploskonka F, Chlebicka I, Szepietowski JC, Jura J. MCPIP1 modulates the miRNA‒mRNA landscape in keratinocyte carcinomas. J Exp Clin Cancer Res. 2024;43(1):290. PubMed PMID: 39428471

9. Szukala W, Lichawska-Cieslar A, Zawada R, Rumienczyk I, Mikula M, Goryca K, Jura J. Keratinocyte and myeloid MCPIP1 have distinct roles in maintaining skin homeostasis. Biochim Biophys Acta Gen Subj. 2024;1868(10):130671. PubMed PMID: 39032853

10. Pydyn N, Ferenc A, Trzos K, Pospiech E, Wilamowski M, Mucha O, Major P, Kadluczka J, Rodrigues PM, Banales JM, Herranz JM, Avila MA, Hutsch T, Malczak P, Radkowiak D, Budzynski A, Jura J, Kotlinowski J. MCPIP1 Inhibits Hepatic Stellate Cell Activation in Autocrine and Paracrine Manners, Preventing Liver Fibrosis. Cell Mol Gastroenterol Hepatol. 2024;17(6):887-906. PubMed PMID: 38311169

11.  Szukala W, Lichawska-Cieslar A, Krajewski PK, Kulecka M, Rumienczyk I, Mikula M, Matusiak Ł, Jura J, Szepietowski JC. An Atlas of the Hidradenitis Suppurativa Transcriptome. Dermatol Ther (Heidelb). 2024. Pubmed PMID: 38183615

12.  Lichawska-Cieslar A, Szukala W, Prajsnar TK, Pooranachandran N, Kulecka M, Dabrowska M, Mikula M, Rakus K, Chadzinska M, Jura J. MCPIP1 functions as a safeguard of early embryonic development. Sci Rep. 2023; 13(1):16944. PubMed PMID: 37805647

13. Mucha O, Skupien-Rabian B, Slota A, Trzos K, Pydyn N, Podlewski B, Jura J, Kotlinowski J. Hepatic Mcpip1 regulates adaptation to food restriction in mice. Acta Biochim Pol. 2023; 70(4):919-925. PubMed PMID: 37929720

14. Pydyn N, Kadluczka J, Major P, Hutsch T, Belamri K, Malczak P, Radkowiak D, Budzynski A, Miekus K, Jura J, Kotlinowski J. Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium. Hepatol Commun. 2023; 7(3):e0008. PubMed PMID: 36809310

15. Szukala W, Rumienczyk I, Mikula M, Goryca K, Eckhart L, Koziel J, Jura J, Lichawska-Cieslar A. MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth. J Invest Dermatol. 2023; 26:S0022-202X(23)03192-5. PubMed PMID: 38154560

16. Szukala W, Pilarczyk-Zurek M, Folkert J, Kotlinowski J, Koziel J, Jura J. Depletion of Mcpip1 in murine myeloid cells results in intestinal dysbiosis followed by allergic inflammation. Biochim Biophys Acta Mol Basis Dis. 2023; 1869(7):166764. PubMed PMID: 37257731

17. Pydyn N, Kadluczka J, Major P, Hutsch T, Belamri K, Malczak P, Radkowiak D, Budzynski A, Miekus K, Jura J, Kotlinowski J. Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium. Hepatol Commun. 2023 Feb 20;7(3):e0008. PubMed PMID: 36809310

18. Marona P, Górka J, Kwapisz O, Jura J, Rys J, Hoffman RM, Miekus K. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation. Cell Death Dis. 2022 Sep 22;13(9):814. PubMed PMID: 36138026

19. Gorka J, Marona P, Kwapisz O, Rys J, Jura J, Miekus K. MCPIP1 regulates focal adhesion kinase and Rho GTPase-dependent migration in clear cell renal cell carcinoma. Eur J Pharmacol. 2022 May 5;922:174804. PubMed PMID: 35257717

20. Trzos K, Pydyn N, Jura J, Kotlinowski J.. Selected transgenic murine models of human autoimmune liver diseases. Pharmacol Rep. 2022 Apr;74(2):263-272. PubMed PMID: 35032321

21. Szukala W, Lichawska-Cieslar A, Pietrzycka R, Kulecka M, Rumienczyk I, Mikula M, Chlebicka I, Konieczny P, Dziedzic K, Szepietowski JC, Fontemaggi G, Rys J, Jura J. Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma. J Exp Clin Cancer Res. 2021 Dec 13;40(1):391. PubMed PMID: 34903245

22. Gorka J, Marona P, Kwapisz O, Waligórska A, Pospiech E, Dobrucki JW, Rys J, Jura J, Miekus K. MCPIP1 inhibits Wnt/β-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs. Oncogene. 2021 Dec;40(50):6720-6735. PubMed PMID: 34657130

23. Krajewski PK, Szukała W, Lichawska-Cieślar A, Matusiak Ł, Jura J, Szepietowski JC. MCPIP1/Regnase-1 Expression in Keratinocytes of Patients with Hidradenitis Suppurativa: Preliminary Results. Int J Mol Sci. 2021 Jul 6;22(14):7241. PubMed PMID: 34298861

24. Gasiorek A, Dobosz E, Potempa B, Ciaston I, Wilamowski M, Oruba Z, Lamont RJ, Jura J, Potempa J, Koziel J. Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts. mBio. 2021 Jun 29;12(3):e0050221. PubMed PMID: 34182783

25. Pydyn N, Żurawek D, Kozieł J, Kus E, Wojnar-Lason K, Jasztal A, Fu M, Jura J, Kotlinowski J. Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts. FEBS J. 2021 Nov;288(22):6563-6580. PubMed PMID: 34058074

26. Dobosz E, Wadowska M, Kaminska M, Wilamowski M, Honarpisheh M, Bryzek D, Potempa J, Jura J, Lech M, Koziel J. MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils. Front Immunol. 2021 Feb 26;12:627922. PubMed PMID: 33717148

27. Kwapisz O, Górka J, Korlatowicz A, Kotlinowski J, Waligórska A, Marona P, Pydyn N, Dobrucki JW, Jura J, Miekus K. Fatty Acids and a High-Fat Diet Induce Epithelial-Mesenchymal Transition by Activating TGFβ and β-Catenin in Liver Cells. Int J Mol Sci. 2021 Jan 28;22(3):1272. PubMed PMID: 33525359

28. Kotlinowski J, Hutsch T, Czyzynska-Cichon I, Wadowska M, Pydyn N, Jasztal A, Kij A, Dobosz E, Lech M, Miekus K, Pośpiech E, Fu M, Jura J, Koziel J, Chlopicki S. Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis. Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166086. PubMed PMID: 33513427

29. Lichawska-Cieslar A, Konieczny P, Szukala W, Declercq W, Fu M, Jura J. Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118866. PubMed PMID: 33007332

30. Musson R, Szukała W, Jura J. MCPIP1 RNase and Its Multifaceted Role. Int J Mol Sci. 2020 Sep 29;21(19):7183. PubMed PMID: 33003343

31. Gorka J, Marona P, Kwapisz O, Rys J, Jura J, Miekus K. The anti-inflammatory protein MCPIP1 inhibits the development of ccRCC by maintaining high levels of tumour suppressors. Eur J Pharmacol. 2020 Dec 5;888:173591. PubMed PMID: 32971087

32. Pajdzik K, Wilamowski M, Żurawek D, Stopa KB, Nodzyński M, Kalita A, Jura J. Anterior gradient 2 promotes tumorigenesis through upregulation of CCAAT-enhancer binding protein beta and hypoxia-inducible factor-2α and subsequent secretion of interleukin-6, interleukin-8, and vascular endothelial growth factor in the Caki-1 clear cell renal cell carcinoma cell line. IUBMB Life. 2020 Aug;72(8):1807-1818. PubMed PMID: 32593213

33. Pydyn N, Miękus K, Jura J, Kotlinowski J.. New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis. Pharmacol Rep. 2020 Feb;72(1):1-12. PubMed PMID: 32016853

34. Losko M, Dolicka D, Pydyn N, Jankowska U, Kedracka-Krok S, Kulecka M, Paziewska A, Mikula M, Major P, Winiarski M, Budzynski A, Jura J. Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism. Cell Mol Life Sci. 2020 Dec;77(23):4899-4919. PubMed PMID: 31893310